Extracellular zinc competitively inhibits manganese uptake and compromises oxidative stress management in Streptococcus pneumoniae.

Streptococcus pneumoniae requires manganese for colonization of the human host, but the underlying molecular basis for this requirement has not been elucidated. Recently, it was shown that zinc could compromise manganese uptake and that zinc levels increased during infection by S. pneumoniae in all...

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Bibliographic Details
Main Authors: Bart A Eijkelkamp, Jacqueline R Morey, Miranda P Ween, Cheryl-lynn Y Ong, Alastair G McEwan, James C Paton, Christopher A McDevitt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24558498/pdf/?tool=EBI