Molecular Targets of the 5-Amido-Carboxamide Bumped Kinase Inhibitor BKI-1748 in <i>Cryptosporidium parvum</i> and HCT-8 Host Cells

Molecular Targets of the 5-Amido-Carboxamide Bumped Kinase Inhibitor BKI-1748 in <i>Cryptosporidium parvum</i> and HCT-8 Host Cells

<i>Cryptosporidium parvum</i> is an apicomplexan parasite causing persistent diarrhea in humans and animals. Issuing from target-based drug development, calcium-dependent protein kinase 1 inhibitors, collectively named bumped kinase inhibitors (BKIs), with excellent efficacies in vitro a...

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Bibliographic Details
Main Authors: Jubilee Ajiboye, Anne-Christine Uldry, Manfred Heller, Arunasalam Naguleswaran, Erkang Fan, Wesley C. Van Voorhis, Andrew Hemphill, Joachim Müller
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
affinity chromatography
binding proteins
proteomics
side effects
splicing
Online Access:https://www.mdpi.com/1422-0067/25/5/2707

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https://www.mdpi.com/1422-0067/25/5/2707

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