Contribution of the Tumor Microenvironment to Metabolic Changes Triggering Resistance of Multiple Myeloma to Proteasome Inhibitors

Contribution of the Tumor Microenvironment to Metabolic Changes Triggering Resistance of Multiple Myeloma to Proteasome Inhibitors

Virtually all patients with multiple myeloma become unresponsive to treatment with proteasome inhibitors over time. Relapsed/refractory multiple myeloma is accompanied by the clonal evolution of myeloma cells with heterogeneous genomic aberrations, diverse proteomic and metabolic alterations, and pr...

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Bibliographic Details
Main Authors: Jonas Schwestermann, Andrej Besse, Christoph Driessen, Lenka Besse
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Oncology
Subjects:
multiple myeloma
tumor microenvironment
proteasome inhibitors
resistance
metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.899272/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.899272/full

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