Phage-Antibiotic Cocktail Rescues Daptomycin and Phage Susceptibility against Daptomycin-Nonsusceptible Enterococcus faecium in a Simulated Endocardial Vegetation Ex Vivo Model

Phage-Antibiotic Cocktail Rescues Daptomycin and Phage Susceptibility against Daptomycin-Nonsusceptible Enterococcus faecium in a Simulated Endocardial Vegetation Ex Vivo Model

ABSTRACT Enterococcus faecium is a difficult-to-treat pathogen with emerging resistance to most clinically available antibiotics. Daptomycin (DAP) is the standard of care, but even high DAP doses (12 mg/kg body weight/day) failed to eradicate some vancomycin-resistant strains. Combination DAP-ceftar...

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Bibliographic Details
Main Authors: Ashlan J. Kunz Coyne, Kyle Stamper, Amer El Ghali, Razieh Kebriaei, Biswajit Biswas, Melanie Wilson, Michael V. Deschenes, Truc T. Tran, Cesar A. Arias, Michael J. Rybak
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:Microbiology Spectrum
Subjects:
bacteriophage
Enterococcus
antibiotic resistance
infective endocarditis
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00340-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.00340-23

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