Molecular Modeling of Cardiac Sodium Channel with Mexiletine

Molecular Modeling of Cardiac Sodium Channel with Mexiletine

A sodium channel blocker mexiletine (MEX) is used to treat chronic pain, myotonia and some arrhythmias. Mutations in the pore domain (PD) of voltage-gated sodium channels differently affect tonic block (TB) and use-dependent block (UDB) by MEX. Previous studies identified several MEX-sensing residue...

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Bibliographic Details
Main Author: Boris S. Zhorov
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Membranes
Subjects:
tonic block
use-dependent block
local anesthetics
molecular modeling
Monte Carlo energy minimizations
voltage-sensing domains
Online Access:https://www.mdpi.com/2077-0375/12/12/1252

Internet

https://www.mdpi.com/2077-0375/12/12/1252

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