M2-polarized tumor-associated macrophages facilitated migration and epithelial-mesenchymal transition of HCC cells via the TLR4/STAT3 signaling pathway

M2-polarized tumor-associated macrophages facilitated migration and epithelial-mesenchymal transition of HCC cells via the TLR4/STAT3 signaling pathway

Abstract Background M2-polarized macrophages are tumor-associated-macrophages (TAMs), which are important contents of tumor-infiltrating immune cells. Toll-like receptor 4 (TLR4) is a molecular biomarker of tumor aggressiveness and poor prognosis. Toll-like receptors (TLRs) have important roles in t...

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Bibliographic Details
Main Authors: Rong-Rong Yao, Jing-Huan Li, Rui Zhang, Rong-Xin Chen, Yan-Hong Wang
Format: Article
Language:English
Published: BMC 2018-01-01
Series:World Journal of Surgical Oncology
Subjects:
Hepatocellular carcinoma
Epithelial-mesenchymal transition
Tumor-associated macrophages
Toll-like receptor 4
Online Access:http://link.springer.com/article/10.1186/s12957-018-1312-y

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http://link.springer.com/article/10.1186/s12957-018-1312-y

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