Duplex Proximity Sequencing (Pro-Seq): A method to improve DNA sequencing accuracy without the cost of molecular barcoding redundancy.

Duplex Proximity Sequencing (Pro-Seq): A method to improve DNA sequencing accuracy without the cost of molecular barcoding redundancy.

A challenge in the clinical adoption of cell-free DNA (cfDNA) liquid biopsies for cancer care is their high cost compared to potential reimbursement. The most common approach used in liquid biopsies to achieve high specificity detection of circulating tumor DNA (ctDNA) among a large background of no...

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Bibliographic Details
Main Authors: Joel Pel, Wendy W Y Choi, Amy Leung, Gosuke Shibahara, Laura Gelinas, Milenko Despotovic, W Lloyd Ung, Andre Marziali
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6168144?pdf=render

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http://europepmc.org/articles/PMC6168144?pdf=render

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