The Na+/Ca2+ Exchanger 3 Is Functionally Coupled With the NaV1.6 Voltage-Gated Channel and Promotes an Endoplasmic Reticulum Ca2+ Refilling in a Transgenic Model of Alzheimer’s Disease

The Na+/Ca2+ Exchanger 3 Is Functionally Coupled With the NaV1.6 Voltage-Gated Channel and Promotes an Endoplasmic Reticulum Ca2+ Refilling in a Transgenic Model of Alzheimer’s Disease

The remodelling of neuronal ionic homeostasis by altered channels and transporters is a critical feature of the Alzheimer’s disease (AD) pathogenesis. Different reports converge on the concept that the Na+/Ca2+ exchanger (NCX), as one of the main regulators of Na+ and Ca2+ concentrations and signall...

Full description

Bibliographic Details
Main Authors: Ilaria Piccialli, Roselia Ciccone, Agnese Secondo, Francesca Boscia, Valentina Tedeschi, Valeria de Rosa, Pasquale Cepparulo, Lucio Annunziato, Anna Pannaccione
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Pharmacology
Subjects:
Na+/Ca2+ exchanger
NCX3
NaV1.6 channels
hippocampal neurons
Alzheimer’s disease
Tg2576 mice
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.775271/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.775271/full

Similar Items