Direct Binding between Pre-S1 and TRP-like Domains in TRPP Channels Mediates Gating and Functional Regulation by PIP2

Direct Binding between Pre-S1 and TRP-like Domains in TRPP Channels Mediates Gating and Functional Regulation by PIP2

Summary: Transient receptor potential (TRP) channels are regulated by diverse stimuli comprising thermal, chemical, and mechanical modalities. They are also commonly regulated by phosphatidylinositol-4,5-bisphosphate (PIP2), with underlying mechanisms largely unknown. We here revealed an intramolecu...

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Bibliographic Details
Main Authors: Wang Zheng, Ruiqi Cai, Laura Hofmann, Vasyl Nesin, Qiaolin Hu, Wentong Long, Mohammad Fatehi, Xiong Liu, Shaimaa Hussein, Tim Kong, Jingru Li, Peter E. Light, Jingfeng Tang, Veit Flockerzi, Leonidas Tsiokas, Xing-Zhen Chen
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:Cell Reports
Subjects:
TRP
pre-S1
TRP domain
intramolecular interaction
electrophysiology
gating
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718300743

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http://www.sciencedirect.com/science/article/pii/S2211124718300743

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