Lipidated PrRP31 metabolites are long acting dual GPR10 and NPFF2 receptor agonists with potent body weight lowering effect

Lipidated PrRP31 metabolites are long acting dual GPR10 and NPFF2 receptor agonists with potent body weight lowering effect

Abstract Prolactin-releasing peptide (PrRP) is an endogenous neuropeptide involved in appetite regulation and energy homeostasis. PrRP binds with high affinity to G-protein coupled receptor 10 (GPR10) and with lesser activity towards the neuropeptide FF receptor type 2 (NPFF2R). The present study ai...

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Bibliographic Details
Main Authors: Flora Alexopoulou, Esben Matzen Bech, Søren Ljungberg Pedersen, Ditte Dencker Thorbek, Ulrike Leurs, Lise Christine Biehl Rudkjær, Keld Fosgerau, Henrik H. Hansen, Niels Vrang, Jacob Jelsing, Lisbeth Elster
Format: Article
Language:English
Published: Nature Portfolio 2022-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-05310-y

Internet

https://doi.org/10.1038/s41598-022-05310-y

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