Decreased synaptic vesicle glycoprotein 2A binding in a rodent model of familial Alzheimer's disease detected by [18F]SDM-16

Decreased synaptic vesicle glycoprotein 2A binding in a rodent model of familial Alzheimer's disease detected by [18F]SDM-16

IntroductionSynapse loss is one of the hallmarks of Alzheimer's disease (AD) and is associated with cognitive decline. In this study, we tested [18F]SDM-16, a novel metabolically stable SV2A PET imaging probe, in the transgenic APPswe/PS1dE9 (APP/PS1) mouse model of AD and age-matched wild-type...

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Bibliographic Details
Main Authors: Chao Zheng, Takuya Toyonaga, Baosheng Chen, LaShae Nicholson, William Mennie, Michael Liu, Joshua Spurrier, Kristin Deluca, Stephen M. Strittmatter, Richard E. Carson, Yiyun Huang, Zhengxin Cai
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Neurology
Subjects:
[18F]SDM-16
APP/PS1
SV2A
PET
brain
SRTM
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2023.1045644/full

Internet

https://www.frontiersin.org/articles/10.3389/fneur.2023.1045644/full

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