Poly-arginine R18 and R18D (D-enantiomer) peptides reduce infarct volume and improves behavioural outcomes following perinatal hypoxic-ischaemic encephalopathy in the P7 rat

Poly-arginine R18 and R18D (D-enantiomer) peptides reduce infarct volume and improves behavioural outcomes following perinatal hypoxic-ischaemic encephalopathy in the P7 rat

Abstract We examined the neuroprotective efficacy of the poly-arginine peptide R18 and its D-enantiomer R18D in a perinatal hypoxic-ischaemic (HI) model in P7 Sprague-Dawley rats. R18 and R18D peptides were administered intraperitoneally at doses of 30, 100, 300 or 1000 nmol/kg immediately after HI...

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Bibliographic Details
Main Authors: Adam B. Edwards, Jane L. Cross, Ryan S. Anderton, Neville W. Knuckey, Bruno P. Meloni
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Molecular Brain
Subjects:
Hypoxic-ischaemic encephalopathy
Hypoxia-ischaemia
Neuroprotection
Poly-arginine peptides
R18
Cationic arginine-rich peptides (CARPs)
Online Access:http://link.springer.com/article/10.1186/s13041-018-0352-0

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http://link.springer.com/article/10.1186/s13041-018-0352-0

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