Genes Associated with Disturbed Cerebral Neurogenesis in the Embryonic Brain of Mouse Models of Down Syndrome
Down syndrome (DS), also known as trisomy 21, is the most frequent genetic cause of intellectual disability. Although the mechanism remains unknown, delayed brain development is assumed to be involved in DS intellectual disability. Analyses with human with DS and mouse models have shown that defects...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-10-01
|
| Series: | Genes |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4425/12/10/1598 |
| _version_ | 1797514528326418432 |
|---|---|
| author | Keiichi Ishihara |
| author_facet | Keiichi Ishihara |
| author_sort | Keiichi Ishihara |
| collection | DOAJ |
| description | Down syndrome (DS), also known as trisomy 21, is the most frequent genetic cause of intellectual disability. Although the mechanism remains unknown, delayed brain development is assumed to be involved in DS intellectual disability. Analyses with human with DS and mouse models have shown that defects in embryonic cortical neurogenesis may lead to delayed brain development. Cre-loxP-mediated chromosomal engineering has allowed the generation of a variety of mouse models carrying various partial Mmu16 segments. These mouse models are useful for determining genotype–phenotype correlations and identifying dosage-sensitive genes involved in the impaired neurogenesis. In this review, we summarize several candidate genes and pathways that have been linked to defective cortical neurogenesis in DS. |
| first_indexed | 2024-03-10T06:32:53Z |
| format | Article |
| id | doaj.art-8e127baeb55f4a4fa60560306b0a1cd9 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T06:32:53Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-8e127baeb55f4a4fa60560306b0a1cd92023-11-22T18:22:30ZengMDPI AGGenes2073-44252021-10-011210159810.3390/genes12101598Genes Associated with Disturbed Cerebral Neurogenesis in the Embryonic Brain of Mouse Models of Down SyndromeKeiichi Ishihara0Department of Pathological Biochemistry, Kyoto Pharmaceutical University, Kyoto 607-8414, JapanDown syndrome (DS), also known as trisomy 21, is the most frequent genetic cause of intellectual disability. Although the mechanism remains unknown, delayed brain development is assumed to be involved in DS intellectual disability. Analyses with human with DS and mouse models have shown that defects in embryonic cortical neurogenesis may lead to delayed brain development. Cre-loxP-mediated chromosomal engineering has allowed the generation of a variety of mouse models carrying various partial Mmu16 segments. These mouse models are useful for determining genotype–phenotype correlations and identifying dosage-sensitive genes involved in the impaired neurogenesis. In this review, we summarize several candidate genes and pathways that have been linked to defective cortical neurogenesis in DS.https://www.mdpi.com/2073-4425/12/10/1598Down syndromeprenatal neurogenesisbrain developmentresponsible genesrelated pathway |
| spellingShingle | Keiichi Ishihara Genes Associated with Disturbed Cerebral Neurogenesis in the Embryonic Brain of Mouse Models of Down Syndrome Genes Down syndrome prenatal neurogenesis brain development responsible genes related pathway |
| title | Genes Associated with Disturbed Cerebral Neurogenesis in the Embryonic Brain of Mouse Models of Down Syndrome |
| title_full | Genes Associated with Disturbed Cerebral Neurogenesis in the Embryonic Brain of Mouse Models of Down Syndrome |
| title_fullStr | Genes Associated with Disturbed Cerebral Neurogenesis in the Embryonic Brain of Mouse Models of Down Syndrome |
| title_full_unstemmed | Genes Associated with Disturbed Cerebral Neurogenesis in the Embryonic Brain of Mouse Models of Down Syndrome |
| title_short | Genes Associated with Disturbed Cerebral Neurogenesis in the Embryonic Brain of Mouse Models of Down Syndrome |
| title_sort | genes associated with disturbed cerebral neurogenesis in the embryonic brain of mouse models of down syndrome |
| topic | Down syndrome prenatal neurogenesis brain development responsible genes related pathway |
| url | https://www.mdpi.com/2073-4425/12/10/1598 |
| work_keys_str_mv | AT keiichiishihara genesassociatedwithdisturbedcerebralneurogenesisintheembryonicbrainofmousemodelsofdownsyndrome |