PD-1/PD-L1 axis induced host immunosuppression via PI3K/Akt/mTOR signalling pathway in piglets infected by Glaesserella Parasuis

PD-1/PD-L1 axis induced host immunosuppression via PI3K/Akt/mTOR signalling pathway in piglets infected by Glaesserella Parasuis

Abstract Glaesserella parasuis, an important respiratory bacterial pathogen, causes Glässer’s disease in piglets, with potential immunosuppression. We established a piglet infection model and explored the immunosuppression mechanism to improve our understanding of the host immune response to G. para...

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Bibliographic Details
Main Authors: Jingyang Li, Siyu Liu, Qiaoli Dong, Yunjian Fu, Yamin Sun, Ronghui Luo, Xinyue Tian, Ling Guo, Wei Liu, Yinsheng Qiu, Qirong Lu, Chun Ye, Bingbing Zong, Shulin Fu
Format: Article
Language:English
Published: BMC 2024-04-01
Series:BMC Veterinary Research
Subjects:
Glaesserella parasuis
Piglets
Spleen
Immunosuppression
Proteomics
Online Access:https://doi.org/10.1186/s12917-024-03993-1

Internet

https://doi.org/10.1186/s12917-024-03993-1

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