LSD1 deletion decreases exosomal PD-L1 and restores T-cell response in gastric cancer

LSD1 deletion decreases exosomal PD-L1 and restores T-cell response in gastric cancer

Abstract Background Histone lysine-specific demethylase 1 (LSD1) expression has been shown to be significantly elevated in gastric cancer (GC) and may be associated with the proliferation and metastasis of GC. It has been reported that LSD1 repressed tumor immunity through programmed cell death 1 li...

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Bibliographic Details
Main Authors: Dan-Dan Shen, Jing-Ru Pang, Ya-Ping Bi, Long-Fei Zhao, Yin-Rui Li, Li-Juan Zhao, Ya Gao, Bo Wang, Ning Wang, Liuya Wei, Huiqin Guo, Hong-Min Liu, Yi-Chao Zheng
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Molecular Cancer
Subjects:
LSD1
PD-L1
Gastric cancer
Exosomes
Tumor immunity
Online Access:https://doi.org/10.1186/s12943-022-01557-1

Internet

https://doi.org/10.1186/s12943-022-01557-1

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