ATRX-Deficient High-Grade Glioma Cells Exhibit Increased Sensitivity to RTK and PDGFR Inhibitors

ATRX-Deficient High-Grade Glioma Cells Exhibit Increased Sensitivity to RTK and PDGFR Inhibitors

High-grade glioma, including anaplastic astrocytoma and glioblastoma (GBM) patients, have a poor prognosis due to the lack of effective treatments. Therefore, the development of new therapeutic strategies to treat these gliomas is urgently required. Given that high-grade gliomas frequently harbor mu...

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Bibliographic Details
Main Authors: David Pladevall-Morera, María Castejón-Griñán, Paula Aguilera, Karina Gaardahl, Andreas Ingham, Jacqueline A. Brosnan-Cashman, Alan K. Meeker, Andres J. Lopez-Contreras
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cancers
Subjects:
glioblastoma
glioma
ATRX
RTKi
PDGFRi
drug screen
Online Access:https://www.mdpi.com/2072-6694/14/7/1790

Internet

https://www.mdpi.com/2072-6694/14/7/1790

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