Reprogramming the tumor microenvironment leverages CD8+ T cell responses to a shared tumor/self antigen in ovarian cancer

Reprogramming the tumor microenvironment leverages CD8+ T cell responses to a shared tumor/self antigen in ovarian cancer

Tumor antigen-driven responses to weakly immunogenic self-antigens and neoantigens directly affect treatment efficacy following immunotherapy. Using orthotopically grown SV40 T antigen+ ovarian carcinoma in antigen-naive wild-type or TgMISIIR-TAg-Low transgenic mice expressing SV40 T antigen as a se...

Full description

Bibliographic Details
Main Authors: Anna Mistarz, Marta Winkler, Sebastiano Battaglia, Song Liu, Alan Hutson, Hanna Rokita, Andrea Gambotto, Kunle O. Odunsi, Prashant K. Singh, A.J. Robert McGray, Jianmin Wang, Danuta Kozbor
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Molecular Therapy: Oncolytics
Subjects:
immunotherapy
ovarian cancer
tolerance
tumor microenvironment
CXCR4 antagonist
oncolityc vaccinia virus
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770523000104

Internet

http://www.sciencedirect.com/science/article/pii/S2372770523000104

Similar Items