Development and in vitro evaluation of Letrozole loaded biodegradable nanoparticles for breast cancer therapy

Development and in vitro evaluation of Letrozole loaded biodegradable nanoparticles for breast cancer therapy

The objectives of our study were to prepare and evaluate a biodegradable nanoparticulate system of Letrozole (LTZ) intended for breast cancer therapy. LTZ loaded poly(lactide-co-glycolide) nanoparticles (LTZ-PLGA-NPs) were prepared by emulsion-solvent evaporation method using methylene chloride and...

Full description

Bibliographic Details
Main Authors:	Sanjoy Kumar Dey, Bivash Mandal, Manas Bhowmik, Lakshmi Kanta Ghosh
Format:	Article
Language:	English
Published:	Universidade de São Paulo 2009-09-01
Series:	Brazilian Journal of Pharmaceutical Sciences
Subjects:	Câncer de mama Letrozol Nanopartícula biodegradável Breast cancer Letrozole Biodegradable nanoparticles
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000300025

Similar Items

Factors associated with nonresponse to ovulation induction using letrozole among women with World Health Organization group II anovulation
by: Thilina Sanjeewa Palihawadana, et al.
Published: (2015-01-01)

Synergistic Combination of Letrozole and Berberine in Ascorbic Acid-Stabilized AuNPs: A Promising Solution for Breast Cancer
by: Ahmed I. Foudah, et al.
Published: (2023-08-01)

The Effect of Letrozole on Symptomatic Uterine Leiomyomas
by: Mansoureh Samimi, et al.
Published: (2013-04-01)

Angioneurotic edema of metastatic breast cancer patient associated with letrozole
by: Yasemin Bakkal Temi, et al.
Published: (2017-12-01)

EVALUATION OF LETROZOLE THERAPEUTIC EFFECT IN INFERTILE WOMEN
by: F. Akbary-Asbagh, et al.
Published: (2007-06-01)

Letrozole versus
by: Hoda Sibai, et al.
Published: (2016-06-01)

Gum Acacia Functionalized Colloidal Gold Nanoparticles of Letrozole as Biocompatible Drug Delivery Carrier for Treatment of Breast Cancer
by: Hibah M. Aldawsari, et al.
Published: (2021-09-01)

Case studies on clinical experience of targeted therapy ribociclib in combination with letrozole in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer
by: M A Frolova, et al.
Published: (2018-06-01)

Effect of Letrozole on Eye Development in Rat Embryos
by: M Mahmoudi, et al.
Published: (2015-03-01)

Real-world comparative effectiveness of palbociclib plus letrozole versus letrozole in older patients with metastatic breast cancer
by: Hope S. Rugo, et al.
Published: (2023-06-01)

The VEGF and PEDF levels in the follicular fluid of patients co- treated with LETROZOLE and gonadotropins during the stimulation cycle
by: Jigal Haas, et al.
Published: (2018-05-01)

Combinatorial Therapy of Letrozole- and Quercetin-Loaded Spanlastics for Enhanced Cytotoxicity against MCF-7 Breast Cancer Cells
by: Aml I. Mekkawy, et al.
Published: (2022-08-01)

Effect of adding letrozole to gonadotropin on in vitro fertilization outcomes: An RCT
by: Maryam Eftekhar, et al.
Published: (2020-04-01)

Beneficial effect of Curcumin in Letrozole induced polycystic ovary syndrome
by: P. Sushma Reddy, et al.
Published: (2016-04-01)

Letrozole as the first-line treatment of infertile women with poly cystic ovarian syndrome (PCOS) compared with clomiphene citrate: A clinical trial
by: Ataollah Ghahiri, et al.
Published: (2016-01-01)

Comparison of ovulation induction with letrozole plus dexamethasone and letrozole alone in infertile women with polycystic ovarian disease: An RCT
by: Farahnaz Farzaneh, et al.
Published: (2020-04-01)

Effects of Letrozole Compared with Danazol on Patients with Confirmed Endometriosis: A Randomized Clinical Trial
by: Mohamad Ali Roghaei, et al.
Published: (2010-07-01)

Design of Novel Letrozole Analogues Targeting Aromatase for Breast Cancer: Molecular Docking, Molecular Dynamics, and Theoretical Studies on Gold Nanoparticles
by: Alaa Edris, et al.
Published: (2023-04-01)

Beneficial effects of Teucrium polium hydroalcoholic extract on letrozole-induced polycystic ovary syndrome in rat model
by: Zeynab Khosrowpour, et al.
Published: (2023-03-01)

A study of controlled ovarian stimulation with clomiphene citrate or letrozole in combination with gonadotropins and IUI in unexplained infertility
by: Madhusmita Hembram, et al.
Published: (2017-01-01)

Comparison of efficacy of letrozole and clomiphene citrate for induction of ovulation
by: Ariana K. Jawad, et al.
Published: (2020-06-01)

The effectiveness of using misoprostol with and without letrozole for successful medical abortion: A randomized placebo-controlled clinical trial
by: Elham Naghshineh, et al.
Published: (2015-01-01)

Effect of letrozole and raloxifene on in vitro human endometrial stromal cells
by: Maryam Pourheydar, et al.
Published: (2020-07-01)

Aromatase inhibitor “letrozole” versus progestin “norethisterone” in women with simple endometrial hyperplasia without atypia: A prospective cohort trial
by: M. El-shamy, et al.
Published: (2012-06-01)

Ovulation induction in women with polycystic ovarian syndrome: Clomiphene citrate or letrozole?
by: Mohamed Y Elsemary, et al.
Published: (2018-01-01)

Pregnancy rates from intrauterine insemination are equivalent following 1- versus 5-day letrozole administration for ovulation induction: a retrospective study
by: Kaitlin McGrail, M.D., et al.
Published: (2020-12-01)

Predictors of response to ovulation induction using letrozole in women with polycystic ovary syndrome
by: Zaixin Guo, et al.
Published: (2023-04-01)

Comparison of the success rate of letrozole and clomiphene citrate in women undergoing intrauterine insemination
by: Robab Davar, et al.
Published: (2006-12-01)

Comparing of letrozole versus clomiphene citrate combined with gonadotropins in intrauterine insemination cycles
by: Fatemeh Ayazi Roozbahani, et al.
Published: (2012-01-01)

EFFECT OF NIGELLA SATIVA ON NUMBER OF CYSTIC FOLLICLES IN LETROZOLE INDUCED POLYCYSTIC OVARIES IN MICE
by: Noreen Anwar, et al.
Published: (2016-06-01)

Letrozole and zoledronic acid changed signalling pathways involved in the apoptosis of breast cancer cells
by: Salah A. Sheweita, PhD, et al.
Published: (2021-02-01)

Formulation and Evaluation of Letrozole Nanoparticles by Salting Out Technique and Determination of Anti-cancer Activity by MTT Assay
by: Amand Alekhya, et al.
Published: (2022-09-01)

Ameliorative Effect of Fenugreek on sex hormones in Polycystic Ovary Syndrome Female Rats Induced by Letrozole
by: Jassim Alkalby, et al.
Published: (2017-12-01)

Comparison of Treatment Outcomes of Infertile Women by Clomiphene Citrate and Letrozole with Gonadotropins Underwent Intrauterine Insemination
by: Seyede Afsar Sharafy, et al.
Published: (2012-01-01)

Joint symptoms associated with anastrozole and letrozole in patients with breast cancer: a retrospective comparative study
by: Yoshihito Morimoto, et al.
Published: (2017-11-01)

SPE–UPLC–MS/MS assay for determination of letrozole in human plasma and its application to bioequivalence study in healthy postmenopausal Indian women
by: Pravin G. Vanol, et al.
Published: (2016-08-01)

Randomized interventional clinical trial to estimate the efficacy of clomiphene citrate versus letrozole in induction of ovulation in infertility
by: Yogindra Kumar Manohar Kabadi, et al.
Published: (2022-07-01)

The state of reproductive organs of young and aged male rats with the prolonged administration of letrozole and after its withdrawal
by: О. H. Reznikov, et al.
Published: (2019-01-01)

Experience of Using Letrozole as a First-Line Ovulation Induction Agent in Polycystic Ovary Syndrome (PCOS)
by: Nupur Nandi *, Mahua Bhattacharya, Amit Tolasaria and Banasree Bhadra
Published: (2011-01-01)

In vitro Development of Controlled-Release Nanoniosomes for Improved Delivery and Anticancer Activity of Letrozole for Breast Cancer Treatment
by: Ahmadi S, et al.
Published: (2022-12-01)