Astragaloside IV attenuates renal tubule injury in DKD rats via suppression of CD36-mediated NLRP3 inflammasome activation

Astragaloside IV attenuates renal tubule injury in DKD rats via suppression of CD36-mediated NLRP3 inflammasome activation

Background:In recent years, diabetic kidney disease (DKD) has emerged as a prominent factor contributing to end-stage renal disease. Tubulointerstitial inflammation and lipid accumulation have been identified as key factors in the development of DKD. Earlier research indicated that Astragaloside IV...

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Bibliographic Details
Main Authors: Xianhong Li, Xin Dong, Liangyou Zhang, Shu Zhang, Weiying Huang, Chao Wang, Zhihao Huo, Xin Li, Xiwen Zhang, Xiaotong Jia, Gangyi Chen, Bin Kuang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Pharmacology
Subjects:
diabetic kidney disease
Astragaloside IV
PA-induced HK-2 cells
CD36
NLRP3 inflammasome
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1285797/full

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https://www.frontiersin.org/articles/10.3389/fphar.2024.1285797/full

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