Recombinant ACE2 Expression Is Required for SARS-CoV-2 To Infect Primary Human Endothelial Cells and Induce Inflammatory and Procoagulative Responses

Recombinant ACE2 Expression Is Required for SARS-CoV-2 To Infect Primary Human Endothelial Cells and Induce Inflammatory and Procoagulative Responses

ABSTRACT SARS-CoV-2 causes COVID-19, an acute respiratory distress syndrome (ARDS) characterized by pulmonary edema, viral pneumonia, multiorgan dysfunction, coagulopathy, and inflammation. SARS-CoV-2 uses angiotensin-converting enzyme 2 (ACE2) receptors to infect and damage ciliated epithelial cell...

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Bibliographic Details
Main Authors: Jonas Nascimento Conde, William R. Schutt, Elena E. Gorbunova, Erich R. Mackow
Format: Article
Language:English
Published: American Society for Microbiology 2020-12-01
Series:mBio
Subjects:
ACE2
COVID-19
SARS-CoV-2
coagulopathy
endothelial cells
endotheliitis
Online Access:https://journals.asm.org/doi/10.1128/mBio.03185-20

Internet

https://journals.asm.org/doi/10.1128/mBio.03185-20

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