Differences in Expansion Potential of Naive Chimeric Antigen Receptor T Cells from Healthy Donors and Untreated Chronic Lymphocytic Leukemia Patients

Differences in Expansion Potential of Naive Chimeric Antigen Receptor T Cells from Healthy Donors and Untreated Chronic Lymphocytic Leukemia Patients

IntroductionTherapy with chimeric antigen receptor T (CART) cells for hematological malignancies has shown promising results. Effectiveness of CART cells may depend on the ratio of naive (TN) vs. effector (TE) T cells, TN cells being responsible for an enduring antitumor activity through maturation....

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Bibliographic Details
Main Authors: Jean-Marc Hoffmann, Maria-Luisa Schubert, Lei Wang, Angela Hückelhoven, Leopold Sellner, Sophia Stock, Anita Schmitt, Christian Kleist, Ulrike Gern, Angelica Loskog, Patrick Wuchter, Susanne Hofmann, Anthony D. Ho, Carsten Müller-Tidow, Peter Dreger, Michael Schmitt
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
chimeric antigen receptor
immunotherapy
CD19
T cell subpopulations
naive T cells
cytokines
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01956/full

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http://journal.frontiersin.org/article/10.3389/fimmu.2017.01956/full

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