ADAM12 promotes clear cell renal cell carcinoma progression and triggers EMT via EGFR/ERK signaling pathway

ADAM12 promotes clear cell renal cell carcinoma progression and triggers EMT via EGFR/ERK signaling pathway

Abstract Background Clear cell renal cell carcinoma (ccRCC) is a major worldwide health problem due to its high prevalence and mortality rate. A disintegrin and metalloproteinase 12 (ADAM12) is aberrantly expressed in various cancers and plays an important role in tumor progression. However, its exp...

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Bibliographic Details
Main Authors: Jinming Xu, Yan Wang, Jiahao Jiang, Cong Yin, Bentao Shi
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Journal of Translational Medicine
Subjects:
ADAM12
EGFR Pathway
EMT
Tumor Progression
Clear cell renal cell carcinoma
Online Access:https://doi.org/10.1186/s12967-023-03913-1

Internet

https://doi.org/10.1186/s12967-023-03913-1

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