Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Induces Intracellular Ca<sup>2+</sup> Release through the Two-Pore Channel TPC1 in Metastatic Colorectal Cancer Cells

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Induces Intracellular Ca<sup>2+</sup> Release through the Two-Pore Channel TPC1 in Metastatic Colorectal Cancer Cells

Nicotinic acid adenine dinucleotide phosphate (NAADP) gates two-pore channels 1 and 2 (TPC1 and TPC2) to elicit endo-lysosomal (EL) Ca<sup>2+</sup> release. NAADP-induced EL Ca<sup>2+</sup> signals may be amplified by the endoplasmic reticulum (ER) through the Ca<sup>2+...

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Bibliographic Details
Main Authors: Pawan Faris, Giorgia Pellavio, Federica Ferulli, Francesca Di Nezza, Mudhir Shekha, Dmitry Lim, Marcello Maestri, Germano Guerra, Luigi Ambrosone, Paolo Pedrazzoli, Umberto Laforenza, Daniela Montagna, Francesco Moccia
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Cancers
Subjects:
NAADP
TPC1
lysosomal Ca<sup>2+</sup> signalling
cancer
colorectal carcinoma
proliferation
Online Access:https://www.mdpi.com/2072-6694/11/4/542

Internet

https://www.mdpi.com/2072-6694/11/4/542

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