CircMYO10 promotes osteosarcoma progression by regulating miR-370-3p/RUVBL1 axis to enhance the transcriptional activity of β-catenin/LEF1 complex via effects on chromatin remodeling

CircMYO10 promotes osteosarcoma progression by regulating miR-370-3p/RUVBL1 axis to enhance the transcriptional activity of β-catenin/LEF1 complex via effects on chromatin remodeling

Abstract Background CircMYO10 is a circular RNA generated by back-splicing of gene MYO10 and is upregulated in osteosarcoma cell lines, but its functional role in osteosarcoma is still unknown. This study aimed to clarify the mechanism of circMYO10 in osteosarcoma. Methods CircMYO10 expression in 10...

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Bibliographic Details
Main Authors: Junxin Chen, Gang Liu, Yizheng Wu, Jianjun Ma, Hongfei Wu, Ziang Xie, Shuai Chen, Yute Yang, Shengyu Wang, Panyang Shen, Yifan Fang, Shunwu Fan, Shuying Shen, Xiangqian Fang
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Molecular Cancer
Subjects:
Osteosarcoma
Circular RNA
circMYO10
RUVBL1
Wnt/β-catenin signaling
EMT
Online Access:http://link.springer.com/article/10.1186/s12943-019-1076-1

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http://link.springer.com/article/10.1186/s12943-019-1076-1

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