Overexpression of TNFα induces senescence, autophagy and mitochondrial dysfunctions in melanoma cells

Overexpression of TNFα induces senescence, autophagy and mitochondrial dysfunctions in melanoma cells

Abstract Background Tumor necrosis factor alpha (TNFα) is a pleiotropic cytokine with both anti-tumorigenic and pro-tumorigenic activity, affecting tumor cell biology, the balance between cell survival and death. The final effect of TNFα is dependent on the type of malignant cells, with the potentia...

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Bibliographic Details
Main Authors: Silvia Tyciakova, Valeria Valova, Barbora Svitkova, Miroslava Matuskova
Format: Article
Language:English
Published: BMC 2021-05-01
Series:BMC Cancer
Subjects:
TNFα
Melanoma
Senescence
Autophagy
Aldehyde dehydrogenase activity
Mitochondrial status
Online Access:https://doi.org/10.1186/s12885-021-08237-1

Internet

https://doi.org/10.1186/s12885-021-08237-1

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