Binding of interferon reduces the force of unfolding for interferon receptor 1.

Differential signaling of the type I interferon receptor (IFNAR) has been correlated with the ability of its subunit, IFNAR1, to differentially recognize a large spectrum of different ligands, which involves intricate conformational re-arrangements of multiple interacting domains. To shed light onto...

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Bibliographic Details
Main Authors: Silvia G Chuartzman, Reinat Nevo, Sharon Waichman, Dalit Shental, Jacob Piehler, Yaakov Levy, Ziv Reich, Ruti Kapon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5389645?pdf=render