Genetic restriction of antigen-presentation dictates allergic sensitization and disease in humanized mice

Genetic restriction of antigen-presentation dictates allergic sensitization and disease in humanized mice

Background: Immunoglobulin(Ig)E-associated allergies result from misguided immune responses against innocuous antigens. CD4+ T lymphocytes are critical for initiating and perpetuating that process, yet the crucial factors determining whether an individual becomes sensitized towards a given allergen...

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Main Authors: Alina Neunkirchner, Bernhard Kratzer, Cordula Köhler, Ursula Smole, Lukas F. Mager, Klaus G. Schmetterer, Doris Trapin, Victoria Leb-Reichl, Edward Rosloniec, Ronald Naumann, Lukas Kenner, Beatrice Jahn-Schmid, Barbara Bohle, Rudolf Valenta, Winfried F. Pickl
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396418301221

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http://www.sciencedirect.com/science/article/pii/S2352396418301221

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