345 The Role of TCF7L2 in Hepatic Metabolic Zonation

OBJECTIVES/GOALS: Single nucleotide polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with Type 2 Diabetes (T2D) and nonalcoholic fatty liver disease (NAFLD). The metabolic function of TCF7L2 in the liver remains to be fully elucidated, but we hypothesized that TCF7L2 c...

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Bibliographic Details
Main Authors: Iriscilla I. Ayala, Skanda K Hebbale, Chris E. Shannon, Ivan Valdez, Marcel Fourcaudot, Terry M. Bakewell, Madelaine Sholto, Thomas Vallim, Sami Heikkinen
Format: Article
Language:English
Published: Cambridge University Press 2023-04-01
Series:Journal of Clinical and Translational Science
Online Access:https://www.cambridge.org/core/product/identifier/S2059866123003898/type/journal_article