Immune System Deficiencies Do Not Alter SARS-CoV-2 Evolutionary Rate but Favour the Emergence of Mutations by Extending Viral Persistence

Immune System Deficiencies Do Not Alter SARS-CoV-2 Evolutionary Rate but Favour the Emergence of Mutations by Extending Viral Persistence

During the COVID-19 pandemic, immunosuppressed patients showed prolonged SARS-CoV-2 infections, with several studies reporting the accumulation of mutations in the viral genome. The weakened immune system present in these individuals, along with the effect of antiviral therapies, are thought to crea...

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Bibliographic Details
Main Authors: Laura Manuto, Martina Bado, Marco Cola, Elena Vanzo, Maria Antonello, Giorgia Mazzotti, Monia Pacenti, Giampaolo Cordioli, Lolita Sasset, Anna Maria Cattelan, Stefano Toppo, Enrico Lavezzo
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Viruses
Subjects:
SARS-CoV-2 genomic variability
viral quasispecies
immunocompromised subjects
intra-host
Online Access:https://www.mdpi.com/1999-4915/16/3/447

Internet

https://www.mdpi.com/1999-4915/16/3/447

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