Design, Synthesis, and Biological Evaluation of Novel 3-Cyanopyridone/Pyrazoline Hybrids as Potential Apoptotic Antiproliferative Agents Targeting EGFR/BRAF<sup>V600E</sup> Inhibitory Pathways

Design, Synthesis, and Biological Evaluation of Novel 3-Cyanopyridone/Pyrazoline Hybrids as Potential Apoptotic Antiproliferative Agents Targeting EGFR/BRAF<sup>V600E</sup> Inhibitory Pathways

A series of novel 3-cyanopyridone/pyrazoline hybrids (<b>21–30</b>) exhibiting dual inhibition against EGFR and BRAF<sup>V600E</sup> has been developed. The synthesized target compounds were tested in vitro against four cancer cell lines. Compounds <b>28</b> and &...

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Bibliographic Details
Main Authors: Lamya H. Al-Wahaibi, Hesham A. Abou-Zied, Mohamed Hisham, Eman A. M. Beshr, Bahaa G. M. Youssif, Stefan Bräse, Alaa M. Hayallah, Mohamed Abdel-Aziz
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Molecules
Subjects:
pyridine
pyrazoline
synthesis
anticancer
apoptosis
docking
Online Access:https://www.mdpi.com/1420-3049/28/18/6586

Internet

https://www.mdpi.com/1420-3049/28/18/6586

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