Development of a human phage display-derived anti-PD-1 scFv antibody: an attractive tool for immune checkpoint therapy

Development of a human phage display-derived anti-PD-1 scFv antibody: an attractive tool for immune checkpoint therapy

Abstract Background The PD-1 checkpoint pathway plays a major role in tumor immune evasion and the development of the tumor microenvironment. Clinical studies show that therapeutic antibodies blocking the PD-1 pathway can restore anti-tumor or anti-virus immune responses by the reinvigoration of exh...

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Bibliographic Details
Main Authors: Sepideh Safaei Ghaderi, Farhad Riazi-Rad, Elmira Safaie Qamsari, Salman Bagheri, Fatemeh Rahimi-Jamnani, Zahra Sharifzadeh
Format: Article
Language:English
Published: BMC 2022-08-01
Series:BMC Biotechnology
Subjects:
PD-1
Single-chain fragment antibody
Immune checkpoint inhibitor
Immunotherapy
Online Access:https://doi.org/10.1186/s12896-022-00752-8

Internet

https://doi.org/10.1186/s12896-022-00752-8

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