TMEM16A Inhibition Preserves Blood–Brain Barrier Integrity After Ischemic Stroke

TMEM16A Inhibition Preserves Blood–Brain Barrier Integrity After Ischemic Stroke

The inflammatory response plays a pivotal role in Blood–Brain Barrier (BBB) destruction following ischemic brain injury. Enhanced leukocyte adhesion to vascular endothelial cells is an essential event in the inflammatory process. TMEM16A, a newly discovered protein regulating calcium-activated chlor...

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Bibliographic Details
Main Authors: Pin-yi Liu, Zhi Zhang, Yi Liu, Xue-lian Tang, Shu Shu, Xin-yu Bao, Yan Zhang, Yue Gu, Yun Xu, Xiang Cao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
blood–brain barrier
transmembrane protein 16A
intercellular adhesion molecule-1
ischemic stroke
NF-κB
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00360/full

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https://www.frontiersin.org/article/10.3389/fncel.2019.00360/full

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