Atorvastatin attenuates ferroptosis-dependent myocardial injury and inflammation following coronary microembolization via the Hif1a/Ptgs2 pathway

Atorvastatin attenuates ferroptosis-dependent myocardial injury and inflammation following coronary microembolization via the Hif1a/Ptgs2 pathway

Objectives: Coronary microembolization (CME) represents a serious periprocedural complication after percutaneous coronary intervention. Ferroptosis has been identified in multiple cardiovascular diseases. In this study, we aimed to investigate the effects of atorvastatin (ATV) on ferroptosis and inf...

Full description

Bibliographic Details
Main Authors:	Tao Liu, Jin Shu, Yangchun Liu, Jian Xie, Tao Li, Haoliang Li, Lang Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-12-01
Series:	Frontiers in Pharmacology
Subjects:	coronary microembolization ferroptosis inflammation atorvastatin myocardial injury
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.1057583/full

Similar Items

Atorvastatin Inhibits Myocardial Apoptosis in a Swine Model of Coronary Microembolization by Regulating PTEN/PI3K/Akt Signaling Pathway
by: Jiangyou Wang, et al.
Published: (2016-01-01)

MiRNA Expression Profile of the Myocardial Tissue of Pigs with Coronary Microembolization
by: Qiang Su, et al.
Published: (2017-10-01)

The Involvement of Phosphatase and Tensin Homolog Deleted on Chromosome Ten (PTEN) in the Regulation of Inflammation Following Coronary Microembolization
by: Jiangyou Wang, et al.
Published: (2014-06-01)

Levosimendan attenuates myocardial injury induced by coronary microembolization in swine by inhibiting myocardial inflammation and apoptosis
by: Han Chen, et al.
Published: (2019-01-01)

Levosimendan Pretreatment Inhibits Myocardial Apoptosis in Swine after Coronary Microembolization
by: Lang Li, et al.
Published: (2017-01-01)

Induction of Myocardial PDCD4 in Coronary Microembolization-Related Cardiac Dysfunction: Evidence from a Large-Animal Study
by: Qiang Su, et al.
Published: (2014-08-01)

Potential Involvement of MiR-30e-3p in Myocardial Injury Induced by Coronary Microembolization via Autophagy Activation
by: Xian-tao Wang, et al.
Published: (2017-12-01)

Effects of the TLR4/Myd88/NF-κB Signaling Pathway on NLRP3 Inflammasome in Coronary Microembolization-Induced Myocardial Injury
by: Qiang Su, et al.
Published: (2018-06-01)

miR-200a-3p Attenuates Coronary Microembolization-Induced Myocardial Injury in Rats by Inhibiting TXNIP/NLRP3-Mediated Cardiomyocyte Pyroptosis
by: Zhi-Qing Chen, et al.
Published: (2021-08-01)

Human Urinary Kallidinogenase Pretreatment Inhibits Myocardial Inflammation and Apoptosis after Coronary Microembolization by Activating PI3K/Akt/FoxO1 Axis
by: Jian Xie, et al.
Published: (2022-10-01)

TAK-242 Protects Against Apoptosis in Coronary Microembolization-Induced Myocardial Injury in Rats by Suppressing TLR4/NF-κB Signaling Pathway
by: Xian-tao Wang, et al.
Published: (2017-03-01)

Proteomics Analysis of Myocardial Tissues in a Mouse Model of Coronary Microembolization
by: Ao Chen, et al.
Published: (2018-09-01)

Colchicine ameliorates myocardial injury induced by coronary microembolization through suppressing pyroptosis via the AMPK/SIRT1/NLRP3 signaling pathway
by: Hongqing Li, et al.
Published: (2024-01-01)

Breviscapine Pretreatment Inhibits Myocardial Inflammation and Apoptosis in Rats After Coronary Microembolization by Activating the PI3K/Akt/GSK-3β Signaling Pathway
by: Chen ZQ, et al.
Published: (2021-02-01)

Atorvastatin Induces Mitochondria-Dependent Ferroptosis via the Modulation of Nrf2-xCT/GPx4 Axis
by: Qi Zhang, et al.
Published: (2022-03-01)

Doppler Microembolic Signals in Behcet\'s Disease with Nervous System Involvement
by: Zahra Mirfeizi, et al.
Published: (2016-06-01)

Resveratrol Pretreatment Inhibits Myocardial Apoptosis in Rats Following Coronary Microembolization via Inducing the PI3K/Akt/GSK-3β Signaling Cascade
by: Li T, et al.
Published: (2021-09-01)

The problem of microembolism in carotid stenting and its solution
by: Yu.V Cherednychenko
Published: (2018-03-01)

Effects of Trimetazidine on PDCD4/NF-κB/TNF-α Pathway in Coronary Microembolization
by: Qiang Su, et al.
Published: (2017-06-01)

Overexpression of lncRNA TUG1 Alleviates NLRP3 Inflammasome-Mediated Cardiomyocyte Pyroptosis Through Targeting the miR-186-5p/XIAP Axis in Coronary Microembolization-Induced Myocardial Damage
by: You Zhou, et al.
Published: (2021-06-01)

Hypoxia-inducible factor-1α attenuates myocardial inflammatory injury in rats induced by coronary microembolization
by: QUAN-FANG CHEN, et al.

The protective effect of activating Nrf2 / HO-1 signaling pathway on cardiomyocyte apoptosis after coronary microembolization in rats
by: Jiabao Liang, et al.
Published: (2017-10-01)

Approaches to classification of microembolic signals in patients recovering from ischemic stroke
by: Ekaterina V. Orlova, et al.
Published: (2023-09-01)

Dynamic changes and the relationship between cardiac function damage and glycogen synthase kinase-3 β expression induced by coronary microembolization in rats
by: Binghui Kong, et al.
Published: (2019-01-01)

Effects of single-dose atorvastatin on interleukin-6, interferon gamma, and myocardial no-reflow in a rabbit model of acute myocardial infarction and reperfusion
by: X.J. Zhao, et al.
Published: (2014-03-01)

Dose-dependent effects of atorvastatin in the hospitalisation period of myocardial infarction
by: O. L. Barbarash, et al.
Published: (2013-06-01)

Alprostadil Injection Attenuates Coronary Microembolization-Induced Myocardial Injury Through GSK-3β/Nrf2/HO-1 Signaling-Mediated Apoptosis Inhibition
by: Qin Z, et al.
Published: (2020-10-01)

Advances in biological markers of ferroptosis in myocardial infarction
by: CHANG Yuchen, LI Jingbo
Published: (2023-04-01)

Protective effects of atorvastatin and quercetin on isoprenaline-induced myocardial infarction in rats
by: Mai A. Zaafan, et al.
Published: (2013-06-01)

Microembolism after Endovascular Treatment of Unruptured Cerebral Aneurysms: Reduction of its Incidence by Microcatheter Lumen Aspiration
by: Dae Yoon Kim, et al.
Published: (2015-09-01)

Microembolizations in the Arterial Cerebral Circulation in Patients with Atrial Fibrillation Ablation Using the Cryoballoon Technique—Protocol and Methodology of a Prospective Observational Study
by: Damir Erkapic, et al.
Published: (2023-05-01)

A Novel Large Animal Model of Thrombogenic Coronary Microembolization
by: Olympia Bikou, et al.
Published: (2019-11-01)

Different effects of air microembolism through patent foramen ovale in patients with migraine: A quantitative electroencephalogram case series
by: Raffaele Ornello, et al.
Published: (2022-12-01)

Granulocyte colony-stimulating factor attenuates myocardial remodeling and ventricular arrhythmia susceptibility via the JAK2-STAT3 pathway in a rabbit model of coronary microembolization
by: Weiwei Wang, et al.
Published: (2020-02-01)

Effect of Very Early Atorvastatin Initiation for Acute Myocardial Infarction on Creatine Kinase release
by: Faris Abdul Kareem, et al.
Published: (2010-06-01)

Resveratrol Attenuate Myocardial Injury by Inhibiting Ferroptosis Via Inducing KAT5/GPX4 in Myocardial Infarction
by: Jing Liu, et al.
Published: (2022-05-01)

ASPECTS OF LIPID-LOWERING THERAPY WITH ATORVASTATIN IN PATIENTS WITH MYOCARDIAL INFARCTION FROM THE PERSPECTIVE OF PERSONALIZED MEDICINE
by: M. V. Solodun, et al.
Published: (2015-09-01)

Klotho protects against aged myocardial cells by attenuating ferroptosis
by: Xicheng Xiong, et al.
Published: (2023-05-01)

Long non‐coding RNA Sox2OT promotes coronary microembolization‐induced myocardial injury by mediating pyroptosis
by: Liying Xuan, et al.
Published: (2022-06-01)

Early effects of atorvastatin on Vitamin D and parathyroid hormone serum levels following acute myocardial infarction
by: Batool Zarei, et al.
Published: (2019-01-01)