Identifying Structural Features of Nucleotide Analogues to Overcome SARS-CoV-2 Exonuclease Activity

Identifying Structural Features of Nucleotide Analogues to Overcome SARS-CoV-2 Exonuclease Activity

With the recent global spread of new SARS-CoV-2 variants, there remains an urgent need to develop effective and variant-resistant oral drugs. Recently, we reported in vitro results validating the use of combination drugs targeting both the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) and proofread...

Full description

Bibliographic Details
Main Authors: Xuanting Wang, Chuanjuan Tao, Irina Morozova, Sergey Kalachikov, Xiaoxu Li, Shiv Kumar, James J. Russo, Jingyue Ju
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Viruses
Subjects:
SARS-CoV-2
coronaviruses
antivirals
RNA-dependent RNA polymerase
exonuclease
nucleotide analogues
Online Access:https://www.mdpi.com/1999-4915/14/7/1413

Internet

https://www.mdpi.com/1999-4915/14/7/1413

Similar Items