Defective AMPK regulation of cholesterol metabolism accelerates atherosclerosis by promoting HSPC mobilization and myelopoiesis

Defective AMPK regulation of cholesterol metabolism accelerates atherosclerosis by promoting HSPC mobilization and myelopoiesis

Objectives: Dysregulation of cholesterol metabolism in the liver and hematopoietic stem and progenitor cells (HSPCs) promotes atherosclerosis development. Previously, it has been shown that HMG-CoA-Reductase (HMGCR), the rate-limiting enzyme in the mevalonate pathway, can be phosphorylated and inact...

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Bibliographic Details
Main Authors: Man K.S. Lee, Olivia D. Cooney, Xuzhu Lin, Shaktypreya Nadarajah, Dragana Dragoljevic, Kevin Huynh, Danise-Ann Onda, Sandra Galic, Peter J. Meikle, Thomas Edlund, Morgan D. Fullerton, Bruce E. Kemp, Andrew J. Murphy, Kim Loh
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Molecular Metabolism
Subjects:
AMPK
Atherosclerosis
HMG-CoA reductase
Cholesterol
HSPCs
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822000837

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http://www.sciencedirect.com/science/article/pii/S2212877822000837

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