Dysregulation of NF-kB in glandular epithelial cells results in Sjögren's-like features.

Dysregulation of NF-kB in glandular epithelial cells results in Sjögren's-like features.

The autoimmune disease primary Sjögren's syndrome (pSS) is characterized by hypofunction of the salivary glands (SGs), the cause of which is not correlated to lymphocytic SG infiltration, as prevailing dogma often states. We knocked out the NF-κB proinflammatory pathway inhibitor A20 in keratin...

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Bibliographic Details
Main Authors: Xiaoyan Wang, Abeer Shaalan, Silvia Liefers, Julie Coudenys, Dirk Elewaut, Gordon B Proctor, Hendrika Bootsma, Frans G M Kroese, Sarah Pringle
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6070175?pdf=render

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http://europepmc.org/articles/PMC6070175?pdf=render

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