Donor derived hematopoietic stem cell niche transplantation facilitates mixed chimerism mediated donor specific tolerance

Donor derived hematopoietic stem cell niche transplantation facilitates mixed chimerism mediated donor specific tolerance

Compelling experimental evidence confirms that the robustness and longevity of mixed chimerism (MC) relies on the persistence and availability of donor-derived hematopoietic stem cell (HSC) niches in recipients. Based on our prior work in rodent vascularized composite allotransplantation (VCA) model...

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Bibliographic Details
Main Authors: Wensheng Zhang, Yong Wang, Fushun Zhong, Xinghuan Wang, Robert Sucher, Cheng-Hung Lin, Gerald Brandacher, Mario G. Solari, Vijay S. Gorantla, Xin Xiao Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Immunology
Subjects:
tolerance
vascularized composite allotransplantation
mixed chimerism
bone marrow transplantation
hematopoietic stem cell niche
thymic central deletion
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1093302/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1093302/full

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