Adenylyl Cyclase Type 8 Overexpression Impairs Phosphorylation-Dependent Orai1 Inactivation and Promotes Migration in MDA-MB-231 Breast Cancer Cells

Adenylyl Cyclase Type 8 Overexpression Impairs Phosphorylation-Dependent Orai1 Inactivation and Promotes Migration in MDA-MB-231 Breast Cancer Cells

Orai1 plays a major role in store-operated Ca<sup>2+</sup> entry (SOCE) in triple-negative breast cancer (TNBC) cells. This channel is inactivated via different mechanisms, including protein kinase C (PKC) and protein kinase A (PKA)-dependent phosphorylation at Ser-27 and Ser-30 or Ser-3...

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Bibliographic Details
Main Authors: Jose Sanchez-Collado, Jose J. Lopez, Isaac Jardin, Pedro J. Camello, Debora Falcon, Sergio Regodon, Gines M. Salido, Tarik Smani, Juan A. Rosado
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cancers
Subjects:
orai1α
adenylyl cyclase 8
store-operated calcium entry
breast cancer cells
migration
Online Access:https://www.mdpi.com/2072-6694/11/11/1624

Internet

https://www.mdpi.com/2072-6694/11/11/1624

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