First-line therapy of chronic myeloid leukemia – focus on dasatinib

Philip C AmreinHematology-Oncology, Massachusetts General Hospital, Boston, USAAbstract: Dasatinib is a broad spectrum, ATP-competitive, tyrosine kinase inhibitor with low nM activity against Bcr-Abl, Src, and other tyrosine kinases. This activity has allowed dasatinib to emerge as one of the most e...

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Bibliographic Details
Main Author: Amrein PC
Format: Article
Language:English
Published: Dove Medical Press 2012-04-01
Series:Blood and Lymphatic Cancer: Targets and Therapy
Online Access:http://www.dovepress.com/first-line-therapy-of-chronic-myeloid-leukemia-ndash-focus-on-dasatini-a9750