Niclosamide prevents the formation of large ubiquitin-containing aggregates caused by proteasome inhibition.

Niclosamide prevents the formation of large ubiquitin-containing aggregates caused by proteasome inhibition.

Protein aggregation is a hallmark of many neurodegenerative diseases and has been linked to the failure to degrade misfolded and damaged proteins. In the cell, aberrant proteins are degraded by the ubiquitin proteasome system that mainly targets short-lived proteins, or by the lysosomes that mostly...

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Bibliographic Details
Main Authors: Esther Gies, Inga Wilde, Jason M Winget, Maria Brack, Barak Rotblat, Carolina Arias Novoa, Aruna D Balgi, Poul H Sorensen, Michel Roberge, Thibault Mayor
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3009716?pdf=render

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http://europepmc.org/articles/PMC3009716?pdf=render

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