Enantioselective Catalytic Aldol Reactions in the Presence of Knoevenagel Nucleophiles: A Chemoselective Switch Optimized in Deep Eutectic Solvents Using Mechanochemistry

Enantioselective Catalytic Aldol Reactions in the Presence of Knoevenagel Nucleophiles: A Chemoselective Switch Optimized in Deep Eutectic Solvents Using Mechanochemistry

In the presence of different nucleophilic Knoevenagel competitors, cyclic and acyclic ketones have been shown to undergo highly chemoselective aldol reactions with aldehydes. In doing so, the substrate breadth for this emerging methodology has been significantly broadened. The method is also no long...

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Bibliographic Details
Main Authors: Hanaa Al Beiruty, Sofiia-Stefaniia Zhylinska, Nino Kutateladze, Hayley Kay Tinn Cheong, José A. Ñíguez, Sarah J. Burlingham, Xavier Marset, Gabriela Guillena, Rafael Chinchilla, Diego A. Alonso, Thomas C. Nugent
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Molecules
Subjects:
organic synthesis
green chemistry
organocatalysis
in-water conditions
deep eutectic solvents
aldol reaction
Online Access:https://www.mdpi.com/1420-3049/29/1/4

Internet

https://www.mdpi.com/1420-3049/29/1/4

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