Assessment of diphenhydramine toxicity – Is its mode of action conserved between human and zebrafish?

Assessment of diphenhydramine toxicity – Is its mode of action conserved between human and zebrafish?

The main aim of the study is to evaluate the effects of the pharmaceutical diphenhydramine (DPH) on embryo-larvae Danio rerio across distinct levels of organization – individual and subcellular – and correlate those effects with the DPH mode of action (MoA) assessed by in silico analysis. An embryos...

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Bibliographic Details
Main Authors: Angela Barreto, Joana Santos, Ana Capitão, Rodrigo Eusébio, Évila Pinheiro Damasceno, Ana Luísa Machado, Luciana S. Rocha, Vânia Calisto, Mónica J.B. Amorim, Vera L. Maria
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Environment International
Subjects:
Pharmaceuticals
Freshwater fish
Multi-biomarkers
Risk evaluation
Mechanisms of toxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S0160412022001891

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http://www.sciencedirect.com/science/article/pii/S0160412022001891

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