Immunization with a highly attenuated replication-competent herpes simplex virus type 1 mutant, HF10, protects mice from genital disease caused by herpes simplex virus type 2

Immunization with a highly attenuated replication-competent herpes simplex virus type 1 mutant, HF10, protects mice from genital disease caused by herpes simplex virus type 2

Genital herpes is an intractable disease caused mainly by herpes simplex virus type 2 (HSV-2), and is a major concern in public health. A previous infection with HSV type 1 (HSV-1) enhances protection against primary HSV-2 infection to some extent. In this study, we evaluated the ability of HF10, a...

Full description

Bibliographic Details
Main Authors: Chenhong eLuo, Fumi eGoshima, Maki eKamakura, Yoshifumi eMutoh, Seiko eIwata, Hiroshi eKimura, Yukihiro eNishiyama
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-04-01
Series:Frontiers in Microbiology
Subjects:
HSV-1
HSV-2
genital herpes
live attenuated vaccine
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2012.00158/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2012.00158/full

Similar Items