Single-molecule characterization of subtype-specific β1 integrin mechanics
Integrins come in subtypes that bind distinct ligands. This work reveals and quantifies subtype-specific mechanical force transmission and assembly of cytoskeleton architectures.
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-35173-w |
| _version_ | 1811207754192257024 |
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| author | Myung Hyun Jo Jing Li Valentin Jaumouillé Yuxin Hao Jessica Coppola Jiabin Yan Clare M. Waterman Timothy A. Springer Taekjip Ha |
| author_facet | Myung Hyun Jo Jing Li Valentin Jaumouillé Yuxin Hao Jessica Coppola Jiabin Yan Clare M. Waterman Timothy A. Springer Taekjip Ha |
| author_sort | Myung Hyun Jo |
| collection | DOAJ |
| description | Integrins come in subtypes that bind distinct ligands. This work reveals and quantifies subtype-specific mechanical force transmission and assembly of cytoskeleton architectures. |
| first_indexed | 2024-04-12T04:09:51Z |
| format | Article |
| id | doaj.art-8e57f82ed97243da9916234023cd3bb0 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T04:09:51Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-8e57f82ed97243da9916234023cd3bb02022-12-22T03:48:32ZengNature PortfolioNature Communications2041-17232022-12-0113111810.1038/s41467-022-35173-wSingle-molecule characterization of subtype-specific β1 integrin mechanicsMyung Hyun Jo0Jing Li1Valentin Jaumouillé2Yuxin Hao3Jessica Coppola4Jiabin Yan5Clare M. Waterman6Timothy A. Springer7Taekjip Ha8Department of Biophysics and Biophysical Chemistry, Johns Hopkins UniversityProgram in Cellular and Molecular Medicine, Boston Children’s HospitalCell and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of HealthProgram in Cellular and Molecular Medicine, Boston Children’s HospitalInstitute for Protein Innovation Harvard Institutes of MedicineProgram in Cellular and Molecular Medicine, Boston Children’s HospitalCell and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of HealthProgram in Cellular and Molecular Medicine, Boston Children’s HospitalDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins UniversityIntegrins come in subtypes that bind distinct ligands. This work reveals and quantifies subtype-specific mechanical force transmission and assembly of cytoskeleton architectures.https://doi.org/10.1038/s41467-022-35173-w |
| spellingShingle | Myung Hyun Jo Jing Li Valentin Jaumouillé Yuxin Hao Jessica Coppola Jiabin Yan Clare M. Waterman Timothy A. Springer Taekjip Ha Single-molecule characterization of subtype-specific β1 integrin mechanics Nature Communications |
| title | Single-molecule characterization of subtype-specific β1 integrin mechanics |
| title_full | Single-molecule characterization of subtype-specific β1 integrin mechanics |
| title_fullStr | Single-molecule characterization of subtype-specific β1 integrin mechanics |
| title_full_unstemmed | Single-molecule characterization of subtype-specific β1 integrin mechanics |
| title_short | Single-molecule characterization of subtype-specific β1 integrin mechanics |
| title_sort | single molecule characterization of subtype specific β1 integrin mechanics |
| url | https://doi.org/10.1038/s41467-022-35173-w |
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