HMGB1-induced activation of ER stress contributes to pulmonary artery hypertension in vitro and in vivo

HMGB1-induced activation of ER stress contributes to pulmonary artery hypertension in vitro and in vivo

Abstract Background HMGB1 and ER stress have been considered to participate in the progression of pulmonary artery hypertension (PAH). However, the molecular mechanism underlying HMGB1 and ER stress in PAH remains unclear. This study aims to explore whether HMGB1 induces pulmonary artery smooth musc...

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Bibliographic Details
Main Authors: Qianqian Zhang, Yuqian Chen, Qingting Wang, Yan Wang, Wei Feng, Limin Chai, Jin Liu, Danyang Li, Huan Chen, Yuanjie Qiu, Nirui Shen, Xiangyu Shi, Xinming Xie, Manxiang Li
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Respiratory Research
Subjects:
Pulmonary artery hypertension
HMGB1
ER stress
Tetramethylpyrazine
Online Access:https://doi.org/10.1186/s12931-023-02454-x

Internet

https://doi.org/10.1186/s12931-023-02454-x

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