A Gadolinium DO3A Amide <i>m</i>-Phenyl Boronic Acid MRI Probe for Targeted Imaging of Sialated Solid Tumors

A Gadolinium DO3A Amide <i>m</i>-Phenyl Boronic Acid MRI Probe for Targeted Imaging of Sialated Solid Tumors

We developed a new probe, Gd-DO3A-Am-PBA, for imaging tumors. Our results showed active targeting of Gd-DO3A-Am-PBA to sialic acid (SA) moieties, with increased cellular labeling in vitro and enhanced tumor accumulation and retention in vivo, compared to the commercial Gadovist. The effectiveness of...

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Bibliographic Details
Main Authors: Christu Rajan, Jaya Seema, Yu-Wen Chen, Tsai-Chen Chen, Ming-Huang Lin, Chia-Huei Lin, Dennis Wen-Han Hwang
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Biomedicines
Subjects:
MRI
contrast agent
CA
DOTA
PBA
SA
Online Access:https://www.mdpi.com/2227-9059/9/10/1459

Internet

https://www.mdpi.com/2227-9059/9/10/1459

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