The Impact of ZIP8 Disease-Associated Variants G38R, C113S, G204C, and S335T on Selenium and Cadmium Accumulations: The First Characterization

The Impact of ZIP8 Disease-Associated Variants G38R, C113S, G204C, and S335T on Selenium and Cadmium Accumulations: The First Characterization

The metal cation symporter ZIP8 (SLC39A8) is a transmembrane protein that imports the essential micronutrients iron, manganese, and zinc, as well as heavy toxic metal cadmium (Cd). It has been recently suggested that selenium (Se), another essential micronutrient that has long been known for its rol...

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Bibliographic Details
Main Authors: Zhan-Ling Liang, Heng Wee Tan, Jia-Yi Wu, Xu-Li Chen, Xiu-Yun Wang, Yan-Ming Xu, Andy T. Y. Lau
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
cadmium cytotoxicity
cancer therapy
cisplatin
ICP-MS
nonsynonymous mutation
selenium homeostasis
Online Access:https://www.mdpi.com/1422-0067/22/21/11399

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https://www.mdpi.com/1422-0067/22/21/11399

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