Contributions of Epstein–Barr Nuclear Antigen 1 (EBNA1) to Cell Immortalization and Survival
Epstein–Barr virus (EBV) immortalizes host cells as part of its latent mode of infection. As a result of this ability to promote cell proliferation and survival, EBV infection contributes to the development of several kinds of B-cell lymphomas and epithelial tumours. The EBV Epstein–Barr nuclear ant...
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-09-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/4/9/1537 |
| _version_ | 1817996204523388928 |
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| author | Lori Frappier |
| author_facet | Lori Frappier |
| author_sort | Lori Frappier |
| collection | DOAJ |
| description | Epstein–Barr virus (EBV) immortalizes host cells as part of its latent mode of infection. As a result of this ability to promote cell proliferation and survival, EBV infection contributes to the development of several kinds of B-cell lymphomas and epithelial tumours. The EBV Epstein–Barr nuclear antigen 1 (EBNA1) protein is the only EBV protein expressed in all EBV-associated tumours and plays multiple important roles in EBV latency. In addition to its well-studied roles in viral DNA replication, segregation and transcriptional activation, several studies have identified roles of EBNA1 in manipulating cellular processes that result in reduced apoptosis and increased cell survival. This review discusses these cellular effects of EBNA1 and mechanisms by which they occur. |
| first_indexed | 2024-04-14T02:18:42Z |
| format | Article |
| id | doaj.art-8e5c8fb029c849b98c2d4368a636e8ff |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-04-14T02:18:42Z |
| publishDate | 2012-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-8e5c8fb029c849b98c2d4368a636e8ff2022-12-22T02:18:05ZengMDPI AGViruses1999-49152012-09-01491537154710.3390/v4091537Contributions of Epstein–Barr Nuclear Antigen 1 (EBNA1) to Cell Immortalization and SurvivalLori FrappierEpstein–Barr virus (EBV) immortalizes host cells as part of its latent mode of infection. As a result of this ability to promote cell proliferation and survival, EBV infection contributes to the development of several kinds of B-cell lymphomas and epithelial tumours. The EBV Epstein–Barr nuclear antigen 1 (EBNA1) protein is the only EBV protein expressed in all EBV-associated tumours and plays multiple important roles in EBV latency. In addition to its well-studied roles in viral DNA replication, segregation and transcriptional activation, several studies have identified roles of EBNA1 in manipulating cellular processes that result in reduced apoptosis and increased cell survival. This review discusses these cellular effects of EBNA1 and mechanisms by which they occur.http://www.mdpi.com/1999-4915/4/9/1537EBNA1USP7PMLp53survivinNm23-H1ROSoxidative stressNFκBSTAT1 |
| spellingShingle | Lori Frappier Contributions of Epstein–Barr Nuclear Antigen 1 (EBNA1) to Cell Immortalization and Survival Viruses EBNA1 USP7 PML p53 survivin Nm23-H1 ROS oxidative stress NFκB STAT1 |
| title | Contributions of Epstein–Barr Nuclear Antigen 1 (EBNA1) to Cell Immortalization and Survival |
| title_full | Contributions of Epstein–Barr Nuclear Antigen 1 (EBNA1) to Cell Immortalization and Survival |
| title_fullStr | Contributions of Epstein–Barr Nuclear Antigen 1 (EBNA1) to Cell Immortalization and Survival |
| title_full_unstemmed | Contributions of Epstein–Barr Nuclear Antigen 1 (EBNA1) to Cell Immortalization and Survival |
| title_short | Contributions of Epstein–Barr Nuclear Antigen 1 (EBNA1) to Cell Immortalization and Survival |
| title_sort | contributions of epstein barr nuclear antigen 1 ebna1 to cell immortalization and survival |
| topic | EBNA1 USP7 PML p53 survivin Nm23-H1 ROS oxidative stress NFκB STAT1 |
| url | http://www.mdpi.com/1999-4915/4/9/1537 |
| work_keys_str_mv | AT lorifrappier contributionsofepsteinbarrnuclearantigen1ebna1tocellimmortalizationandsurvival |