Effect of etoposide on grass pea DNA topoisomerase II: an in silico, in vivo, and in vitro assessments

Effect of etoposide on grass pea DNA topoisomerase II: an in silico, in vivo, and in vitro assessments

Abstract Background Etoposide is one of the most potential anti-cancerous drugs that targets topoisomerase II (topoII) and inhibits its activity by ligation with the DNA molecule. Results In silico study confirmed that the etoposide-binding sites of topoII are conserved among the plants and human. T...

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Bibliographic Details
Main Authors: Aveek Samanta, Tilak Raj Maity, Sudip Das, Animesh Kumar Datta, Siraj Datta
Format: Article
Language:English
Published: SpringerOpen 2019-12-01
Series:Bulletin of the National Research Centre
Subjects:
Callus growth kinetics
Etoposide
Lathyrus sativus L.
Mitotic index
Topoisomerase II
Topoisomerase assay
Online Access:https://doi.org/10.1186/s42269-019-0217-4

Internet

https://doi.org/10.1186/s42269-019-0217-4

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