Dynamic relocalization of replication origins by Fkh1 requires execution of DDK function and Cdc45 loading at origins
Chromosomal DNA elements are organized into spatial domains within the eukaryotic nucleus. Sites undergoing DNA replication, high-level transcription, and repair of double-strand breaks coalesce into foci, although the significance and mechanisms giving rise to these dynamic structures are poorly un...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2019-05-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/45512 |